PPG 0.2 TAB

About

PPG 0.2 TAB likely refers to Pioglitazone 0.2 mg, an oral antidiabetic medication belonging to the thiazolidinedione class. It is primarily used in the management of Type 2 Diabetes Mellitus. This condition is characterized by insulin resistance, where the body's cells do not respond effectively to insulin, leading to elevated blood glucose levels. Pioglitazone works by activating peroxisome proliferator-activated receptor gamma (PPARγ) in adipose tissue, skeletal muscle, and the liver.

Activation of PPARγ enhances the sensitivity of these tissues to insulin, thereby improving glucose uptake and utilization. This action helps to lower blood glucose levels and reduce insulin resistance, without directly stimulating insulin secretion from the pancreas. Pioglitazone also has beneficial effects on lipid metabolism, modestly reducing triglyceride levels and increasing high-density lipoprotein (HDL) cholesterol. It is often used as monotherapy or in combination with other antidiabetic agents to achieve optimal glycemic control.

Uses

• Treatment of Type 2 Diabetes Mellitus.
• Improvement of insulin sensitivity.
• Reduction of elevated blood glucose levels.
• Used as monotherapy or in combination therapy.

Directions For Use

Take PPG 0.2 TAB orally once daily, with or without food, as prescribed by your healthcare provider.

Benefits

• Enhances insulin sensitivity in peripheral tissues.
• Effectively lowers fasting and post-meal blood glucose.
• Reduces HbA1c levels over time.
• Does not cause hypoglycemia when used alone.
• May have beneficial effects on lipid profile.
• Provides sustained glycemic control.

Side Effects

• Fluid retention and edema.
• Weight gain.
• Increased risk of heart failure.
• Increased risk of bone fractures (especially in women).
• Upper respiratory tract infection.
• Headache.
• Sinusitis.
• Muscle pain.
• Bladder cancer (rare, with long-term use).
• Macular edema (rare).
• Hypoglycemia (when combined with insulin or sulfonylureas).
• Anemia.

Safety Measures

• Alcohol - Moderate alcohol intake is generally permissible, but monitor blood glucose levels as alcohol can affect them.
• Pregnancy - Not recommended during pregnancy; insulin is generally preferred for glycemic control in pregnant women with diabetes.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if pioglitazone passes into breast milk and its effects on the infant.
• Liver - Contraindicated in patients with active liver disease or elevated liver enzymes; liver function should be monitored before and during treatment.
• Kidney - Generally safe for use in patients with kidney impairment; no dose adjustment is typically required for mild to moderate renal dysfunction.
• Lung - Contraindicated in patients with symptomatic heart failure (NYHA Class III or IV) due to increased risk of fluid retention and exacerbation of heart failure.

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