Rituxy 500mg Injection

About

Rituximab is a chimeric monoclonal antibody that specifically targets the CD20 antigen, a transmembrane protein found on the surface of pre-B and mature B-lymphocytes, but not on hematopoietic stem cells or plasma cells. By binding to CD20, rituximab initiates a cascade of immune responses, including antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and direct induction of apoptosis, ultimately leading to the selective depletion of CD20-positive B-cells. This targeted B-cell depletion is a crucial therapeutic strategy in treating various B-cell non-Hodgkin lymphomas, chronic lymphocytic leukemia, and a range of autoimmune diseases such as rheumatoid arthritis and granulomatosis with polyangiitis, where B-cells play a significant pathogenic role. Its mechanism helps to effectively control disease progression, reduce inflammatory activity, and restore immune balance by removing the disease-driving B-cell population.

Uses

• Non-Hodgkin Lymphoma
• Chronic Lymphocytic Leukemia
• Rheumatoid Arthritis
• Granulomatosis with Polyangiitis

Directions For Use

Administer via intravenous infusion under strict medical supervision. Dosage and infusion rate depend on the specific condition and patient response.

Benefits

• Induces remission in certain lymphomas
• Reduces disease activity in autoimmune conditions
• Improves symptoms of rheumatoid arthritis
• Targets specific disease-causing B-cells
• Can be used in combination therapies
• Offers long-term disease control for some patients

Side Effects

• Infusion-related reactions (fever, chills, nausea)
• Fatigue
• Headache
• Nausea
• Diarrhea
• Increased risk of infections
• Peripheral edema
• Hypotension
• Pruritus
• Rash
• Neutropenia
• Progressive multifocal leukoencephalopathy (PML)

Safety Measures

• Alcohol - No specific contraindication, but avoid excessive alcohol, especially if liver function is compromised or other medications are taken.
• Pregnancy - Not recommended during pregnancy due to potential B-cell depletion in the fetus. Effective contraception is advised during and after treatment.
• Breastfeeding - Avoid breastfeeding during treatment and for several months after the last dose, as it may be excreted in breast milk.
• Liver - Use with caution in patients with impaired liver function. Regular monitoring of liver enzymes may be necessary.
• Kidney - No specific dose adjustment is typically required for renal impairment, but monitor kidney function, especially with concomitant nephrotoxic drugs.
• Lung - Use with caution in patients with pre-existing pulmonary conditions, as infusion reactions can affect respiratory function.

Disclaimer

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