Temcad 250mg Capsule

About

Temozolomide is an oral alkylating antineoplastic agent primarily used in the treatment of certain brain tumors. As a prodrug, it undergoes rapid chemical conversion at physiological pH to its active metabolite, 5-(3-methyl-1-triazen-1-yl)imidazole-4-carboxamide (MTIC). MTIC then exerts its cytotoxic effects by methylating DNA at various sites, particularly at the O6 and N7 positions of guanine. This methylation leads to DNA damage and subsequent repair attempts by the cell. When these repair mechanisms are overwhelmed or faulty, it results in DNA strand breaks, cell cycle arrest, and ultimately apoptosis, particularly in rapidly proliferating cancer cells. Its ability to cross the blood-brain barrier makes it particularly effective for central nervous system malignancies. It is often used in combination with radiation therapy for newly diagnosed glioblastoma multiforme and as monotherapy for refractory anaplastic astrocytoma.

Uses

• Newly diagnosed glioblastoma multiforme
• Refractory anaplastic astrocytoma
• Other malignant gliomas
• Certain neuroendocrine tumors (off-label)

Directions For Use

Take orally, usually once daily on an empty stomach. Follow your doctor's dosing schedule precisely.

Benefits

• Oral administration for convenience
• Crosses the blood-brain barrier effectively
• Demonstrated efficacy in brain tumors
• Can be used in combination with radiotherapy
• Improved progression-free survival
• Manageable side effect profile

Side Effects

• Nausea and vomiting
• Fatigue
• Headache
• Constipation or diarrhea
• Myelosuppression (low blood counts)
• Thrombocytopenia
• Neutropenia
• Anorexia
• Rash
• Alopecia
• Opportunistic infections
• Increased liver enzymes

Safety Measures

• Alcohol - Avoid or limit alcohol due to potential for increased gastrointestinal upset and liver strain.
• Pregnancy - Contraindicated. May cause fetal harm. Use effective contraception.
• Breastfeeding - Not recommended. Excreted in breast milk, potential for serious adverse reactions in infant.
• Liver - Use with caution in patients with severe hepatic impairment; dose adjustments may be necessary.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustments may be necessary.
• Lung - Generally not a primary concern, but monitor for any new or worsening respiratory symptoms, especially with prolonged use or in immunocompromised patients.

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