Temomaps 20mg Capsule

About

Temozolomide is an oral alkylating agent used in the treatment of certain aggressive brain tumors, including newly diagnosed glioblastoma multiforme and refractory anaplastic astrocytoma. It functions as a prodrug that rapidly converts to its active metabolite, MTIC (5-(3-methyl-1-triazen-1-yl)imidazole-4-carboxamide), at physiological pH within the body. MTIC exerts its potent cytotoxic effects by methylating DNA at various critical sites, primarily at the O6 and N7 positions of guanine. This specific methylation leads to DNA damage and subsequent apoptosis (programmed cell death) in rapidly dividing tumor cells, thereby inhibiting tumor growth. Temozolomide's unique ability to effectively cross the blood-brain barrier makes it particularly valuable and effective for treating central nervous system malignancies. It is often used in combination with radiation therapy for newly diagnosed glioblastoma, significantly improving patient outcomes and survival rates.

Uses

• Newly diagnosed glioblastoma multiforme.
• Refractory anaplastic astrocytoma.
• Concomitant therapy with radiation for glioblastoma.
• Maintenance therapy following initial treatment for glioblastoma.

Directions For Use

Take orally on an empty stomach, usually once daily for a specified number of days per cycle. Swallow capsules whole with water.

Benefits

• Effective against aggressive brain tumors.
• Can cross the blood-brain barrier.
• Improves progression-free survival in glioblastoma.
• Extends overall survival in glioblastoma patients.
• Oral administration offers convenience.
• Part of standard treatment protocols for specific brain cancers.

Side Effects

• Nausea
• Vomiting
• Fatigue
• Headache
• Constipation
• Anorexia
• Myelosuppression (low blood counts)
• Thrombocytopenia (low platelets)
• Neutropenia (low neutrophils)
• Lymphopenia (low lymphocytes)
• Alopecia (hair loss)
• Opportunistic infections (e.g., PCP)

Safety Measures

• Alcohol - Avoid or limit alcohol as it may worsen gastrointestinal side effects and potentially interact with the medication.
• Pregnancy - Contraindicated due to significant risk of fetal harm. Effective contraception is required during and after treatment.
• Breastfeeding - Not recommended due to the potential for serious adverse reactions in the breastfed infant.
• Liver - Use with caution in patients with severe hepatic impairment; liver function should be monitored regularly.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustments may be necessary.
• Lung - Rare but serious pulmonary toxicity (e.g., pneumonitis) can occur; monitor for respiratory symptoms.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.