TENDIA M FORTE

About

Tendia M Forte combines Teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and a higher dose of Metformin, a biguanide, to provide robust glycemic control for adults with type 2 diabetes mellitus. Teneligliptin works by inhibiting the enzyme DPP-4, thereby increasing the levels of active incretin hormones, which enhance glucose-dependent insulin secretion and suppress glucagon release. Metformin, in its higher dose, more potently reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. This powerful combination addresses multiple pathophysiological defects of type 2 diabetes, making it suitable for patients requiring more intensive glycemic management, particularly those who have not achieved adequate control with lower doses or other therapies.

Uses

• Intensive management of type 2 diabetes mellitus.
• Significant improvement of glycemic control.
• Used as an add-on to diet and exercise.
• For patients requiring higher Metformin doses.

Directions For Use

Take this medication orally, usually once or twice daily with meals, as directed by your doctor.

Benefits

• Potent blood sugar reduction.
• Enhanced insulin sensitivity.
• Strong reduction in hepatic glucose production.
• Low risk of hypoglycemia (when used alone).
• Convenient fixed-dose combination.
• Aids in achieving stringent HbA1c targets.

Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Fatigue
• Vomiting
• Metallic taste
• Lactic acidosis (rare, with Metformin)
• Pancreatitis (rare, with Teneligliptin)
• Joint pain
• Skin reactions

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can significantly increase the risk of lactic acidosis, especially with higher Metformin doses, and may cause hypoglycemia.
• Pregnancy - Generally not recommended during pregnancy. Consult a doctor; benefits must outweigh potential risks.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk. Seek medical advice.
• Liver - Use with caution in patients with mild to moderate hepatic impairment. Contraindicated in severe liver disease due to increased risk of lactic acidosis.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment required for moderate impairment.
• Lung - Use with caution in conditions causing hypoxia, which can increase the risk of lactic acidosis.

Disclaimer

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