Thromplat 50mg Tablet

About

Thromplat 50mg Tablet contains clopidogrel, an antiplatelet agent that works by selectively and irreversibly inhibiting the binding of adenosine diphosphate (ADP) to its platelet receptor (P2Y12). This inhibition prevents the activation of the glycoprotein IIb/IIIa complex, thereby inhibiting platelet aggregation. Clopidogrel is a prodrug that requires metabolic activation by cytochrome P450 enzymes, primarily CYP2C19, to its active metabolite. It is widely used in cardiovascular medicine to prevent thrombotic events in patients with atherosclerotic disease, reducing the risk of myocardial infarction, stroke, and vascular death. Its efficacy in preventing secondary cardiovascular events makes it a cornerstone in the management of various arterial thrombotic conditions.

Uses

• Prevention of atherothrombotic events in patients with recent MI.
• Prevention of atherothrombotic events in patients with recent stroke.
• Prevention of atherothrombotic events in patients with established peripheral arterial disease.
• Used in combination with aspirin for acute coronary syndrome.

Directions For Use

Take orally, usually once daily, with or without food. Do not crush or chew.

Benefits

• Reduces risk of heart attack and stroke.
• Prevents blood clot formation.
• Effective for various cardiovascular conditions.
• Can be used long-term.
• Well-established efficacy.
• Oral administration.

Side Effects

• Bleeding (e.g., bruising, nosebleeds).
• Gastrointestinal upset (e.g., abdominal pain, diarrhea).
• Dyspepsia.
• Rash.
• Pruritus.
• Headache.
• Dizziness.
• Nausea.
• Vomiting.
• Thrombotic thrombocytopenic purpura (TTP) (rare).
• Neutropenia (rare).
• Hemorrhagic stroke (rare).

Safety Measures

• Alcohol - Avoid excessive alcohol consumption, as it can increase the risk of gastrointestinal bleeding when combined with antiplatelet agents like clopidogrel.
• Pregnancy - Use only if clearly needed. Animal studies show no direct harmful effects, but human data are limited. Consult a doctor to weigh risks and benefits.
• Breastfeeding - Not recommended. It is unknown if clopidogrel is excreted in human milk. Due to potential for serious adverse reactions in infants, breastfeeding should be discontinued.
• Liver - Use with caution in patients with severe hepatic impairment, as clopidogrel is metabolized in the liver.
• Kidney - Use with caution in patients with renal impairment. No dose adjustment is generally needed, but close monitoring is advised.
• Lung - No specific contraindications or precautions related to lung conditions.

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