VICEMIC M 500

About

Metformin 500mg is an oral biguanide medication widely used as a first-line treatment for type 2 diabetes mellitus. Its primary mechanism of action involves decreasing glucose production in the liver, particularly by inhibiting gluconeogenesis and glycogenolysis. Additionally, it reduces glucose absorption from the intestines and significantly improves the body's sensitivity to insulin in peripheral tissues, such as muscle and fat cells.

This multifaceted action helps to lower elevated blood sugar levels and improve glycemic control without typically causing weight gain or hypoglycemia when used as monotherapy. Metformin is a cornerstone of diabetes management due to its proven efficacy, favorable safety profile, and potential cardiovascular benefits. It is often prescribed as an adjunct to diet and exercise to help patients achieve and maintain target blood glucose levels.

Uses

• Management of type 2 diabetes mellitus.
• To improve glycemic control.
• As an adjunct to diet and exercise.
• Off-label for polycystic ovary syndrome (PCOS).

Directions For Use

Take orally with meals, usually two to three times daily, or as directed by your doctor.

Benefits

• Effectively lowers blood glucose.
• Improves insulin sensitivity.
• Does not cause weight gain.
• Low risk of hypoglycemia.
• Reduces cardiovascular risk.
• Can be used long-term.

Side Effects

• Nausea.
• Vomiting.
• Diarrhea.
• Abdominal pain.
• Metallic taste.
• Loss of appetite.
• Lactic acidosis (rare but serious).
• Vitamin B12 deficiency.
• Headache.
• Dizziness.
• Weakness.
• Flatulence.

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it significantly increases the risk of lactic acidosis, a serious side effect.
• Pregnancy - Generally considered safe for some pregnant women with gestational diabetes or PCOS, but always consult your doctor.
• Breastfeeding - Considered generally safe; minimal amounts are excreted into breast milk, unlikely to harm the infant.
• Liver - Use with caution in patients with liver impairment due to an increased risk of lactic acidosis.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to the high risk of lactic acidosis.
• Lung - Generally safe for use in patients with lung conditions; no specific pulmonary contraindications.

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