VILDAPRIDE M-500 TAB

About

VILDAPRIDE M-500 TAB is a combination medication used to manage type 2 diabetes mellitus. It contains Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin, a biguanide. Vildagliptin works by enhancing the body's own ability to control blood glucose levels by increasing the active levels of incretin hormones, which stimulate insulin release and suppress glucagon secretion in a glucose-dependent manner. Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues. This dual mechanism of action provides comprehensive glycemic control, targeting multiple pathways involved in glucose dysregulation in type 2 diabetes, leading to improved fasting and post-prandial blood sugar levels.

Uses

• Treatment of type 2 diabetes mellitus.
• As an adjunct to diet and exercise.
• When monotherapy with Metformin or Vildagliptin is insufficient.
• To improve glycemic control in adults.

Directions For Use

Take orally, usually with meals to minimize gastrointestinal upset. Follow your doctor's prescribed dosage and schedule strictly.

Benefits

• Improved HbA1c levels.
• Dual mechanism of action for comprehensive control.
• Reduced fasting and post-prandial glucose.
• Potential for weight neutrality or modest weight loss.
• Lower risk of hypoglycemia compared to sulfonylureas.
• Convenient combination therapy.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Metallic taste
• Headache
• Dizziness
• Nasopharyngitis
• Joint pain
• Skin rash
• Fatigue
• Lactic acidosis (rare but serious)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption due to increased risk of lactic acidosis, especially with Metformin.
• Pregnancy - Generally not recommended during pregnancy; consult a doctor. Use only if potential benefits outweigh risks.
• Breastfeeding - Not recommended as components may pass into breast milk. Consult a healthcare professional.
• Liver - Use with caution; Metformin is contraindicated in severe hepatic impairment. Vildagliptin may require dose adjustment.
• Kidney - Metformin is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Vildagliptin requires dose adjustment based on renal function.
• Lung - Severe respiratory insufficiency can increase the risk of lactic acidosis with Metformin.

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