Zecyte 250mg Tablet

About

Abiraterone acetate is a crucial androgen biosynthesis inhibitor specifically designed for the treatment of metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC). Its therapeutic action stems from its ability to potently inhibit cytochrome P450 17A1 (CYP17A1), an enzyme that plays a pivotal role in the biosynthesis of androgens in the testes, adrenal glands, and within prostate tumor tissue itself. By significantly reducing the production of androgens, abiraterone acetate effectively starves prostate cancer cells, which are highly dependent on these hormones for their growth and proliferation, thereby slowing disease progression. It is typically administered orally in combination with a corticosteroid like prednisone, which helps to mitigate potential side effects related to mineralocorticoid excess, such as hypertension and hypokalemia, ensuring a more tolerable treatment regimen.

Uses

• Metastatic castration-resistant prostate cancer (mCRPC).
• Metastatic high-risk castration-sensitive prostate cancer (mCSPC).
• Used in combination with prednisone.
• Reduces androgen production.

Directions For Use

Take orally on an empty stomach, at least one hour before or two hours after food. Take with prednisone as prescribed.

Benefits

• Significantly prolongs survival in mCRPC.
• Reduces prostate-specific antigen (PSA) levels.
• Oral administration for patient convenience.
• Effective in both pre- and post-chemotherapy settings.
• Improves quality of life.
• Targets androgen production pathways.

Side Effects

• Fatigue
• Joint swelling/discomfort
• Hot flashes
• Diarrhea
• Hypertension (high blood pressure)
• Hypokalemia (low potassium)
• Fluid retention
• Liver enzyme elevation
• Urinary tract infection
• Hypertriglyceridemia
• Adrenal insufficiency (when discontinuing prednisone)
• Cardiac disorders (e.g., arrhythmia)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption, as it may exacerbate liver side effects.
• Pregnancy - Contraindicated for pregnant women; can cause fetal harm. Women of childbearing potential should avoid contact with crushed or broken tablets.
• Breastfeeding - Not applicable for male patients. For female caregivers, avoid contact with the drug.
• Liver - Use with caution and dose adjustment in moderate hepatic impairment; contraindicated in severe hepatic impairment.
• Kidney - No dose adjustment required for mild to moderate renal impairment; use with caution in severe impairment.
• Lung - No specific contraindications or dose adjustments related to lung conditions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.