Ziluta 150mg Tablet

About

Nilutamide is a non-steroidal antiandrogen medication primarily indicated for the treatment of metastatic prostate cancer. Its mechanism of action involves competitively binding to androgen receptors located in target tissues, including prostate cancer cells. By occupying these receptors, nilutamide effectively blocks the binding and subsequent action of endogenous androgens, such as testosterone and dihydrotestosterone, which are crucial for stimulating the growth and proliferation of androgen-dependent prostate cancer cells. This blockade leads to an inhibition of tumor growth and can induce regression or stabilization of the disease. Nilutamide is typically used in conjunction with surgical castration (orchiectomy) or medical castration (achieved with GnRH analogues) to achieve maximal androgen blockade, a strategy aimed at completely suppressing androgenic stimulation of the tumor. Administered orally, it undergoes extensive hepatic metabolism. Its targeted action makes it an important component in the management of advanced prostate cancer, particularly in patients requiring comprehensive androgen deprivation therapy.

Uses

• Metastatic prostate cancer
• Used in combination with surgical or medical castration
• Androgen-dependent prostate cancer
• Advanced prostate cancer

Directions For Use

Take orally once daily as prescribed by your doctor. May be taken with or without food.

Benefits

• Effective in treating metastatic prostate cancer.
• Blocks androgen receptor activity.
• Can be used in combination with other therapies.
• Helps control tumor growth and progression.
• Oral administration for patient convenience.
• Improves quality of life in advanced disease.

Side Effects

• Hot flashes
• Nausea
• Constipation
• Diarrhea
• Hepatotoxicity (liver damage)
• Interstitial pneumonitis (lung inflammation)
• Visual disturbances (impaired dark adaptation)
• Alcohol intolerance (disulfiram-like reaction)
• Dizziness
• Headache
• Breast tenderness/gynecomastia
• Fatigue

Safety Measures

• Alcohol - Avoid alcohol completely due to a disulfiram-like reaction (flushing, nausea, vomiting, hypotension).
• Pregnancy - Not applicable for male patients. Should not be handled by pregnant women.
• Breastfeeding - Not applicable for male patients.
• Liver - Contraindicated in patients with severe hepatic impairment. Monitor liver function closely.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustments may be needed.
• Lung - Monitor for signs of interstitial pneumonitis (e.g., dyspnea, cough); discontinue if suspected.

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