ZITEN M 20/500 TAB 10 S

About

ZITEN M 20/500 TAB is a combination oral antidiabetic medication containing Teneligliptin 20mg and Metformin 500mg, prescribed for the management of Type 2 Diabetes Mellitus. Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by increasing the levels of incretin hormones (GLP-1 and GIP) in the body. These hormones enhance glucose-dependent insulin secretion from the pancreas and suppress glucagon secretion, leading to improved blood glucose control. Metformin, a biguanide, complements this action by reducing glucose production in the liver and improving insulin sensitivity in peripheral tissues.

This synergistic combination addresses multiple pathophysiological defects in Type 2 diabetes, offering comprehensive glycemic management. It is particularly beneficial for patients who have not achieved adequate blood sugar control with diet, exercise, or monotherapy. By effectively lowering both fasting and post-meal blood glucose levels, ZITEN M 20/500 helps to reduce HbA1c and minimize the risk of long-term complications associated with uncontrolled diabetes, such as cardiovascular events, kidney disease, and nerve damage, thereby improving patient outcomes and quality of life.

Uses

• Management of Type 2 Diabetes Mellitus.
• When diet and exercise alone are insufficient.
• When monotherapy with Teneligliptin or Metformin is inadequate.
• To improve glycemic control and reduce HbA1c.

Directions For Use

Take orally with meals, usually once or twice daily, as directed by your physician. Swallow the tablet whole without crushing or chewing.

Benefits

• Provides dual mechanism for effective glucose control.
• Significantly reduces HbA1c levels.
• Low risk of hypoglycemia (due to Teneligliptin).
• Helps prevent long-term diabetes complications.
• Weight neutral or potential for modest weight loss (due to Metformin).
• Convenient dosing for better patient adherence.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Metallic taste in mouth
• Lactic acidosis (rare, serious, due to Metformin)
• Headache
• Dizziness
• Nasopharyngitis (common cold symptoms)
• Pancreatitis (rare, due to Teneligliptin)
• Skin rash
• Constipation
• Vitamin B12 deficiency (long-term Metformin use)
• Dyspepsia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to increased risk of lactic acidosis with Metformin.
• Pregnancy - Generally not recommended during pregnancy; insulin is usually preferred. Consult your doctor immediately if pregnant or planning pregnancy.
• Breastfeeding - Not recommended during breastfeeding as Metformin passes into breast milk. Consult your doctor.
• Liver - Use with caution in moderate hepatic impairment; contraindicated in severe hepatic impairment due to Metformin.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to Metformin accumulation and risk of lactic acidosis.
• Lung - Use with caution in severe respiratory conditions that may predispose to hypoxia and increase the risk of lactic acidosis.

Disclaimer

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