Adricin 10mg Injection

About

Doxorubicin is an anthracycline topoisomerase inhibitor widely utilized in the treatment of various malignancies. Its mechanism of action involves intercalating into DNA, inhibiting topoisomerase II, and generating reactive oxygen species, which collectively lead to DNA damage, impaired replication, and ultimately, programmed cell death. This cytotoxic effect makes it a potent agent against rapidly proliferating cancer cells. It is administered intravenously and undergoes extensive metabolism primarily in the liver, with biliary excretion being the major elimination pathway. Due to its broad spectrum of activity, doxorubicin is a cornerstone in many chemotherapy regimens, contributing significantly to disease control and patient outcomes across a range of cancers. Careful monitoring for potential toxicities, particularly cardiotoxicity, is crucial during its administration, alongside managing other common side effects like myelosuppression and mucositis. Its efficacy, despite its toxicity profile, underscores its importance in oncology.

Uses

• Breast cancer
• Lymphomas (Hodgkin's and non-Hodgkin's)
• Leukemias (acute lymphoblastic and myeloid)
• Sarcomas (osteosarcoma, soft tissue sarcoma)

Directions For Use

Administered intravenously by a healthcare professional. Dosage and frequency depend on the specific cancer, patient's condition, and other treatments.

Benefits

• Broad-spectrum anticancer activity.
• Effective in various solid tumors and hematologic malignancies.
• Often used as a component of combination chemotherapy regimens.
• Can induce significant tumor regression.
• Improves survival rates in certain cancers.
• Well-established efficacy profile.

Side Effects

• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Cardiotoxicity (dose-dependent, cumulative)
• Nausea and vomiting
• Alopecia (hair loss)
• Mucositis/stomatitis
• Fatigue
• Red urine (harmless, due to drug color)
• Injection site reactions
• Diarrhea or constipation
• Hand-foot syndrome
• Secondary malignancies
• Hypersensitivity reactions

Safety Measures

• Alcohol - Avoid or limit alcohol due to potential for increased liver toxicity and gastrointestinal irritation.
• Pregnancy - Contraindicated. May cause fetal harm. Effective contraception is required during and after treatment.
• Breastfeeding - Not recommended. The drug can pass into breast milk and harm the infant.
• Liver - Use with caution; dosage adjustments may be necessary in patients with hepatic impairment due to altered metabolism and increased toxicity risk.
• Kidney - Use with caution; dosage adjustments may be necessary in patients with renal impairment, though primarily hepatically cleared.
• Lung - Use with caution in patients with pre-existing lung conditions, though direct pulmonary toxicity is less common than with some other chemotherapies.

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