AGLIPT M 15

About

AGLIPT M 15 likely refers to a combination medication containing a dipeptidyl peptidase-4 (DPP-4) inhibitor (e.g., Alogliptin, Sitagliptin) and Metformin, used for the comprehensive management of type 2 diabetes mellitus. Metformin primarily works by decreasing hepatic glucose production, reducing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. The DPP-4 inhibitor enhances the body's natural ability to lower blood glucose by increasing the levels of incretin hormones, which stimulate insulin release and suppress glucagon secretion in a glucose-dependent manner.

This dual action provides robust glycemic control, addressing multiple pathophysiological defects inherent in type 2 diabetes. The combination effectively helps to reduce both fasting and post-meal blood glucose levels, leading to significant improvements in HbA1c values. It is typically prescribed as an adjunct to diet and exercise when monotherapy with either agent alone is insufficient to achieve adequate glycemic targets, offering a convenient and effective treatment option.

Uses

• Management of type 2 diabetes mellitus
• Improved glycemic control
• Reduction of HbA1c levels
• Adjunct to diet and exercise

Directions For Use

Take orally with meals, usually twice daily, as directed by your physician. Swallow the tablet whole; do not crush or chew.

Benefits

• Comprehensive blood sugar control
• Reduces fasting glucose
• Lowers post-meal glucose
• Improves insulin sensitivity
• Low risk of hypoglycemia (alone)
• Convenient combination therapy

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Nasopharyngitis
• Upper respiratory tract infection
• Hypoglycemia (especially with other agents)
• Lactic acidosis (rare, with Metformin)
• Pancreatitis (rare, with gliptins)
• Joint pain
• Rash

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis with Metformin.
• Pregnancy - Not recommended during pregnancy; consult a doctor for alternative management.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk; consult a doctor.
• Liver - Use with caution in patients with liver impairment; Metformin is contraindicated in severe liver disease.
• Kidney - Metformin is contraindicated in severe renal impairment; dose adjustment or discontinuation may be necessary.
• Lung - No specific contraindications, but monitor for respiratory symptoms if lactic acidosis is suspected.

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