DPVIL M 500 10S

About

DPVIL M 500 is a potent fixed-dose combination therapy for type 2 diabetes mellitus, comprising vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin hydrochloride, a biguanide. Vildagliptin enhances the body's intrinsic ability to regulate blood glucose by inhibiting the DPP-4 enzyme, which prolongs the activity of incretin hormones like GLP-1 and GIP. These hormones play a crucial role in glucose homeostasis by stimulating insulin release from pancreatic beta cells and suppressing glucagon secretion from alpha cells, both in a glucose-dependent manner. Metformin, on the other hand, primarily acts by reducing hepatic glucose production, decreasing intestinal glucose absorption, and improving insulin sensitivity in peripheral tissues, thereby increasing glucose uptake and utilization. This complementary action of vildagliptin and metformin provides comprehensive glycemic control, effectively lowering both fasting and post-meal blood glucose levels. It is indicated for adults with type 2 diabetes when diet and exercise alone, or monotherapy with either vildagliptin or metformin, do not provide adequate glycemic control, offering a robust and convenient treatment option.

Uses

• Treatment of type 2 diabetes mellitus.
• As an adjunct to diet and exercise.
• When monotherapy with metformin or vildagliptin is inadequate.
• To improve glycemic control in adults.

Directions For Use

Take with meals to minimize gastrointestinal side effects, usually twice daily, or as directed by your physician. Swallow tablets whole.

Benefits

• Provides dual mechanism for blood glucose control.
• Effectively lowers HbA1c levels.
• Reduces post-meal glucose spikes.
• Low risk of hypoglycemia when used alone.
• May lead to modest weight loss (due to metformin).
• Convenient fixed-dose combination.

Side Effects

• Nausea.
• Diarrhea.
• Abdominal pain.
• Headache.
• Dizziness.
• Tremor.
• Fatigue.
• Nasopharyngitis.
• Pancreatitis (rare).
• Lactic acidosis (rare, due to metformin).
• Vitamin B12 deficiency (with long-term metformin use).
• Liver enzyme elevations (rare, with vildagliptin).

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it can increase the risk of lactic acidosis, a rare but serious side effect of metformin.
• Pregnancy - Not recommended during pregnancy; consult a doctor to discuss alternative treatments for gestational diabetes or pre-existing diabetes.
• Breastfeeding - Both components may pass into breast milk; not recommended during breastfeeding. Consult a healthcare professional.
• Liver - Vildagliptin is not recommended in patients with liver impairment; metformin is contraindicated in severe liver disease due to increased risk of lactic acidosis.
• Kidney - Metformin is contraindicated in severe kidney impairment (eGFR <30 mL/min/1.73m²); dose adjustment is required for moderate impairment.
• Lung - No specific lung-related contraindications; however, ensure overall health status is monitored.

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