Augplat 125mg Injection

About

Amoxicillin/Clavulanate is a potent combination antibiotic, pairing amoxicillin, a penicillin-class beta-lactam antibiotic, with clavulanic acid, a crucial beta-lactamase inhibitor. This synergistic combination significantly broadens amoxicillin's antibacterial spectrum by neutralizing beta-lactamase enzymes, which are often produced by resistant bacteria to inactivate penicillin-type antibiotics. Consequently, Augplat is highly effective against a wide array of Gram-positive and Gram-negative bacteria, including many common pathogens that have developed resistance to amoxicillin alone. The injectable formulation is specifically designed for the treatment of more severe or complicated bacterial infections, or for patients who are unable to tolerate oral medication. It ensures rapid systemic delivery and achieves therapeutic concentrations quickly, working by disrupting bacterial cell wall synthesis, which ultimately leads to bacterial cell lysis and death. This makes it a vital tool in combating serious infections across various body systems.

Uses

• Treatment of severe bacterial infections.
• Management of complicated skin and soft tissue infections.
• Therapy for hospital-acquired pneumonia.
• Treatment of complicated urinary tract infections.

Directions For Use

Administer intravenously as directed by a healthcare professional. The dosage and duration of treatment depend on the infection type and severity.

Benefits

• Broad-spectrum antibacterial activity.
• Effective against beta-lactamase producing bacteria.
• Rapid onset of action via injection.
• Suitable for severe infections.
• Reduces bacterial resistance development.
• Versatile for various infection sites.

Side Effects

• Nausea
• Diarrhea
• Vomiting
• Abdominal pain
• Rash
• Urticaria
• Injection site reactions (pain, swelling)
• Headache
• Dizziness
• Elevated liver enzymes
• Candidiasis
• Clostridium difficile-associated diarrhea

Safety Measures

• Alcohol - Concurrent alcohol consumption is generally discouraged as it may exacerbate gastrointestinal side effects and potentially mask symptoms of adverse reactions.
• Pregnancy - Use during pregnancy should only be considered if clearly needed, after a thorough risk-benefit assessment by a physician, as animal studies are not always predictive of human response.
• Breastfeeding - Small amounts of amoxicillin and clavulanate may pass into breast milk. Caution is advised, and a physician should be consulted to monitor for potential infant side effects like diarrhea or rash.
• Liver - Use with caution in patients with pre-existing liver impairment. Regular monitoring of liver function tests is recommended, and the medication should be discontinued if liver injury occurs.
• Kidney - Dosage adjustment is necessary for patients with renal impairment to prevent accumulation and potential toxicity. Renal function should be assessed before and during treatment.
• Lung - No specific contraindications related to primary lung conditions, but it is commonly used to treat bacterial lung infections.

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