Fibrodone 801mg Tablet

About

Pirfenidone, often marketed as Fibrodone, is a groundbreaking antifibrotic agent specifically indicated for the treatment of idiopathic pulmonary fibrosis (IPF). IPF is a severe, chronic, and progressive interstitial lung disease characterized by the irreversible scarring and thickening of lung tissue, leading to a relentless decline in lung function and ultimately, respiratory failure. While its exact mechanism of action remains incompletely elucidated, pirfenidone is understood to exert its therapeutic effects through multiple pathways involved in fibrosis and inflammation. It significantly inhibits the synthesis of key pro-fibrotic cytokines, such as transforming growth factor-beta (TGF-β), which is a potent stimulator of fibroblast proliferation and extracellular matrix deposition. Additionally, it reduces the production of tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine. By modulating these critical mediators, pirfenidone effectively attenuates fibroblast proliferation, decreases collagen synthesis, and reduces the accumulation of other extracellular matrix components, thereby slowing the rate of lung function decline and disease progression in patients with IPF.

Uses

• Treatment of idiopathic pulmonary fibrosis (IPF)
• Slows the progression of lung function decline
• Reduces the risk of disease progression
• Improves progression-free survival in IPF

Directions For Use

Take orally, usually three times daily with food to reduce nausea. Follow a dose escalation schedule as prescribed by your doctor.

Benefits

• Slows the decline in lung function
• Reduces disease progression in IPF
• Decreases mortality risk in IPF patients
• Improves exercise tolerance in some individuals
• Offers a targeted treatment for a severe condition
• Helps manage symptoms associated with fibrosis

Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Fatigue
• Headache
• Dizziness
• Photosensitivity reaction (rash, sunburn)
• Elevated liver enzymes
• Anorexia
• Dyspepsia
• Vomiting
• Insomnia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can increase the risk of liver damage, a potential side effect of pirfenidone.
• Pregnancy - Not recommended during pregnancy due to potential risks; use only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding - It is unknown if pirfenidone passes into breast milk; breastfeeding is not recommended during treatment.
• Liver - Contraindicated in severe hepatic impairment; requires regular monitoring of liver function tests and dose adjustment in moderate impairment.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustment may be necessary, and it is contraindicated in end-stage renal disease requiring dialysis.
• Lung - Specifically used for lung fibrosis; however, monitor for worsening respiratory symptoms or new lung infections during treatment.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.