GLUCORYL M3 FORTE 10'S

About

Glucoryl M3 Forte is a combination medication used in the management of type 2 diabetes mellitus. It combines glimepiride, a sulfonylurea, and metformin, a biguanide, offering a synergistic approach to blood glucose control. Glimepiride works by stimulating the pancreatic beta cells to release more insulin, thereby lowering blood glucose levels, particularly after meals. Metformin acts primarily by reducing glucose production in the liver, decreasing glucose absorption from the intestine, and improving insulin sensitivity in peripheral tissues, which helps the body use insulin more effectively. This dual mechanism of action provides comprehensive glycemic control, making it particularly effective when diet, exercise, and monotherapy with either agent are insufficient to achieve target blood sugar levels. The "Forte" designation typically indicates a higher strength formulation, designed for patients requiring more intensive glucose lowering to prevent long-term complications associated with uncontrolled diabetes.

Uses

• Management of type 2 diabetes mellitus in adults.
• When diet and exercise alone are inadequate.
• When monotherapy with glimepiride or metformin is insufficient.
• To improve glycemic control in patients with uncontrolled blood sugar.

Directions For Use

Take orally with meals, as prescribed by your doctor. Swallow the tablet whole with water; do not crush or chew.

Benefits

• Effectively lowers fasting and post-meal blood glucose.
• Improves the body's response to insulin.
• Reduces glucose production by the liver.
• Helps prevent long-term complications of diabetes.
• Offers a convenient fixed-dose combination therapy.
• Contributes to better overall glycemic control.

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Metallic taste in mouth
• Weight gain
• Skin rash
• Lactic acidosis (rare but serious)
• Vitamin B12 deficiency (with long-term metformin use)
• Flatulence

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to increased risk of hypoglycemia and lactic acidosis.
• Pregnancy - Generally not recommended during pregnancy; consult your doctor for safer alternatives.
• Breastfeeding - Not advised during breastfeeding as components may pass into breast milk.
• Liver - Use with caution in patients with liver impairment; increased risk of lactic acidosis and hypoglycemia.
• Kidney - Contraindicated in severe renal impairment; dose adjustment required for moderate impairment.
• Lung - Use with caution in severe respiratory conditions due to potential for lactic acidosis.

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