Grafeel 300mcg Injection PFS

About

Grafeel 300mcg Injection PFS (Pre-filled Syringe) contains Filgrastim, a recombinant human granulocyte colony-stimulating factor (G-CSF). This biological agent functions by stimulating the bone marrow to produce, mature, and release neutrophils, which are vital white blood cells essential for combating bacterial and fungal infections. Filgrastim achieves this by binding to specific G-CSF receptors on hematopoietic stem cells and myeloid progenitor cells, thereby promoting their proliferation and differentiation.

The pre-filled syringe format offers convenience and ease of administration, particularly for self-administration or in outpatient settings, ensuring accurate dosing and reducing preparation time. It is primarily indicated for the prevention and treatment of neutropenia, a common and serious side effect of myelosuppressive chemotherapy, and in other conditions where an increase in neutrophil count is clinically beneficial. By elevating neutrophil levels, it significantly lowers the risk of febrile neutropenia and associated infections.

Uses

• Prevention of febrile neutropenia after chemotherapy.
• Mobilization of hematopoietic progenitor cells for collection.
• Treatment of severe chronic neutropenia.
• Reduction of infection risk in patients undergoing bone marrow transplantation.

Directions For Use

Administer subcutaneously as directed by your healthcare professional. Ensure proper aseptic technique and follow instructions for self-administration if applicable.

Benefits

• Convenient pre-filled syringe for easy use.
• Reduces the incidence and severity of infections.
• Accelerates neutrophil recovery post-chemotherapy.
• Supports continuation of cancer treatment regimens.
• Improves patient quality of life by reducing complications.
• Reliable and consistent increase in neutrophil counts.

Side Effects

• Bone pain
• Muscle aches
• Fatigue
• Headache
• Nausea
• Vomiting
• Diarrhea
• Splenomegaly
• Thrombocytopenia
• Injection site pain
• Acute respiratory distress syndrome (rare)
• Allergic reactions

Safety Measures

• Alcohol - No known direct interaction with alcohol. However, it is generally prudent to avoid or limit alcohol during active medical treatment.
• Pregnancy - Filgrastim should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. Consult your doctor.
• Breastfeeding - It is not known whether Filgrastim is excreted in human milk. Caution should be exercised when administering to a breastfeeding woman.
• Liver - No specific dose adjustment is typically required for patients with hepatic impairment, but clinical monitoring is recommended in severe cases.
• Kidney - No specific dose adjustment is generally necessary for patients with renal impairment, but caution is advised in severe renal dysfunction.
• Lung - Rare but serious pulmonary adverse reactions, including ARDS, have been reported. Use with caution in patients with pre-existing lung conditions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.