INTAGLIPT 50 10S

About

Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor prescribed for the management of type 2 diabetes mellitus. Its therapeutic action stems from inhibiting the enzyme DPP-4, which plays a crucial role in the inactivation of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By preventing the breakdown of these naturally occurring hormones, sitagliptin effectively increases their active concentrations. This leads to enhanced glucose-dependent insulin secretion from the pancreatic beta cells and a reduction in glucagon secretion from the pancreatic alpha cells, particularly after meals. The net effect is a significant improvement in glycemic control, characterized by lower fasting and postprandial blood glucose levels. It is typically used as an adjunct to diet and exercise, either alone or in combination with other antidiabetic medications, providing a targeted approach to glucose regulation.

Uses

• Management of type 2 diabetes mellitus.
• Used as monotherapy or in combination with other antidiabetic agents.
• To improve glycemic control in adults.
• When diet and exercise alone are insufficient.

Directions For Use

Take Sitagliptin 50mg orally once daily, with or without food, as directed by your healthcare provider.

Benefits

• Effectively lowers blood glucose levels.
• Low risk of hypoglycemia when used as monotherapy.
• Generally well-tolerated.
• Can be used with or without food.
• Helps improve pancreatic beta-cell function.
• Does not typically cause weight gain.

Side Effects

• Upper respiratory tract infection
• Nasopharyngitis
• Headache
• Diarrhea
• Nausea
• Abdominal pain
• Joint pain
• Back pain
• Hypoglycemia (when combined with sulfonylureas or insulin)
• Pancreatitis (rare)
• Allergic reactions (rare)
• Skin rash

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake can affect blood sugar levels and should be discussed with a doctor.
• Pregnancy - Limited data available. Use only if the potential benefit justifies the potential risk to the fetus. Consult a physician.
• Breastfeeding - It is unknown if Sitagliptin is excreted in human milk. Exercise caution and consult a healthcare provider.
• Liver - No dose adjustment is typically required for mild to moderate hepatic impairment. Use with caution in severe impairment.
• Kidney - Dose adjustment is necessary for patients with moderate to severe renal impairment and end-stage renal disease.
• Lung - No specific contraindications related to lung conditions.

Disclaimer

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