Lucaparib 200mg Tablet

About

Lucaparib 200mg Tablet is a targeted antineoplastic agent belonging to the class of poly (ADP-ribose) polymerase (PARP) inhibitors. It functions by inhibiting PARP enzymes, which are crucial for DNA repair in cells, particularly single-strand break repair. This inhibition leads to the accumulation of DNA damage, especially in cancer cells with existing homologous recombination repair deficiencies, such as those carrying BRCA1/2 mutations. By selectively targeting these vulnerable cancer cells, Lucaparib induces synthetic lethality, preventing effective DNA repair and ultimately leading to programmed cell death. This precise mechanism makes it a valuable therapeutic option in specific cancer types, significantly improving progression-free survival and overall response rates in eligible patients, particularly in the context of maintenance therapy or advanced disease. It represents a key advancement in precision oncology.

Uses

• Treatment of ovarian cancer with BRCA mutations.
• Management of metastatic breast cancer with germline BRCA mutations.
• Therapy for metastatic castration-resistant prostate cancer.
• Adjuvant treatment for pancreatic cancer with BRCA mutations.

Directions For Use

Take Lucaparib 200mg Tablet orally, exactly as prescribed by your physician, usually twice daily. Do not crush, chew, or break the tablet.

Benefits

• Targets specific cancer cells with DNA repair deficiencies.
• Improves progression-free survival in eligible patients.
• Offers a targeted therapy option for certain advanced cancers.
• Can be effective in patients who have failed prior therapies.
• Generally well-tolerated compared to traditional chemotherapy.
• Provides a significant clinical benefit in BRCA-mutated cancers.

Side Effects

• Nausea
• Fatigue
• Anemia
• Vomiting
• Diarrhea
• Abdominal pain
• Decreased appetite
• Headache
• Myelosuppression
• Dyspepsia
• Rash
• Taste disturbance

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or interact with the medication's metabolism.
• Pregnancy - Lucaparib is contraindicated in pregnancy due to potential fetal harm. Effective contraception must be used during treatment and for a period after.
• Breastfeeding - Breastfeeding is not recommended during treatment with Lucaparib and for a specified period after the last dose, due to potential harm to the infant.
• Liver - Use with caution in patients with hepatic impairment. Dose adjustments may be necessary based on the severity of liver dysfunction.
• Kidney - Use with caution in patients with renal impairment. Dose adjustments may be required depending on the degree of kidney function.
• Lung - Monitor for new or worsening respiratory symptoms, as interstitial lung disease or pneumonitis can occur rarely.

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