Nitib 140mg Capsule

About

Nitib 140mg Capsule is a potent multi-targeted receptor tyrosine kinase (RTK) inhibitor, designed to interfere with several signaling pathways involved in cancer cell growth, angiogenesis, and metastasis. It works by blocking the activity of various kinases, including those associated with vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), and other oncogenic kinases. This comprehensive inhibition leads to a reduction in tumor blood supply, direct inhibition of cancer cell proliferation, and prevention of tumor spread. It is typically used in the treatment of various solid tumors where these pathways are aberrantly activated.

The broad spectrum of kinase inhibition makes Nitib 140mg Capsule effective against a range of cancers, particularly those that are resistant to other therapies or have progressed. Its mechanism of action helps to stabilize disease and improve patient outcomes by disrupting multiple critical processes essential for tumor survival and growth. Close monitoring for adverse effects, especially cardiovascular and dermatological toxicities, is crucial to ensure patient safety and optimize the therapeutic regimen.

Uses

• Treatment of advanced renal cell carcinoma (RCC).
• Management of hepatocellular carcinoma (HCC).
• Treatment of gastrointestinal stromal tumors (GIST) after imatinib failure.
• Therapy for differentiated thyroid carcinoma (DTC) refractory to radioactive iodine.

Directions For Use

Take Nitib 140mg Capsule orally once daily, with or without food, as prescribed by your doctor. Swallow the capsule whole; do not open, crush, or chew it.

Benefits

• Inhibits multiple cancer-promoting kinases.
• Reduces tumor angiogenesis.
• Slows tumor growth and metastasis.
• Effective in various advanced solid tumors.
• May improve progression-free survival.
• Offers a targeted treatment option.

Side Effects

• Fatigue
• Diarrhea
• Hypertension
• Hand-foot skin reaction
• Nausea
• Vomiting
• Decreased appetite
• Weight loss
• Stomatitis
• Dysphonia (hoarseness)
• Hypothyroidism
• Proteinuria

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or interact with the medication, potentially affecting liver function.
• Pregnancy - Nitib 140mg Capsule is contraindicated during pregnancy due to potential embryofetal toxicity. Women of childbearing potential must use highly effective contraception.
• Breastfeeding - Breastfeeding is not recommended during treatment with Nitib 140mg Capsule and for at least 2 weeks after the last dose, as the drug may be excreted in breast milk.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary, and liver function should be monitored regularly.
• Kidney - Caution is advised in patients with severe renal impairment; dose modifications may be required based on kidney function.
• Lung - Monitor for new or worsening respiratory symptoms, as interstitial lung disease or pneumonitis can be a rare but serious side effect.

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