PEG-LASGEN 3750IU Injection

About

PEG-LASGEN 3750IU Injection is a modified enzyme preparation, specifically a pegylated form of L-asparaginase. L-asparaginase functions by depleting asparagine, an amino acid that is essential for the growth and survival of certain cancer cells, particularly lymphoblasts found in acute lymphoblastic leukemia (ALL). By depriving these rapidly dividing cells of asparagine, the enzyme inhibits protein synthesis and ultimately leads to cell death. The pegylation process extends the half-life of the enzyme in the body, allowing for less frequent administration compared to the native form of asparaginase and potentially reducing its immunogenicity. This medication is a crucial component of multi-agent chemotherapy regimens for the treatment of ALL in both pediatric and adult patients.

Uses

• Acute Lymphoblastic Leukemia (ALL)
• Lymphoma (certain types, e.g., non-Hodgkin lymphoma)
• Induction therapy for ALL
• Relapsed or refractory ALL

Directions For Use

Administer intravenously or intramuscularly as directed by a healthcare professional. Do not shake the vial.

Benefits

• Essential component in ALL treatment.
• Prolonged half-life due to pegylation.
• Less frequent dosing compared to native asparaginase.
• Induces remission in ALL.
• Targets specific metabolic pathway in cancer cells.
• Part of established chemotherapy protocols.

Side Effects

• Hypersensitivity reactions (anaphylaxis)
• Pancreatitis
• Hyperglycemia
• Coagulopathy (bleeding or thrombosis)
• Liver dysfunction
• Nausea and vomiting
• Abdominal pain
• Fatigue
• Rash
• Peripheral neuropathy
• Renal dysfunction
• Hyperammonemia

Safety Measures

• Alcohol - Avoid alcohol as it may increase the risk of pancreatitis or liver toxicity, which are known side effects of this medication.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm. Use effective contraception during treatment and for a period after.
• Breastfeeding - Not recommended during breastfeeding due to potential harm to the infant; it is unknown if the drug is excreted in human milk.
• Liver - Monitor liver function closely; this medication may cause significant hepatotoxicity, including elevated transaminases and bilirubin.
• Kidney - Use with caution; monitor renal function as it can cause kidney impairment, though less common than other toxicities.
• Lung - Rarely, pulmonary toxicity, including interstitial lung disease, can occur; monitor for respiratory symptoms.

Disclaimer

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