SITARA M 50/500 10S

About

SITARA M 50/500 is a combination oral antidiabetic medication containing Sitagliptin (50mg) and Metformin (500mg), indicated for the management of type 2 diabetes mellitus in adults. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by enhancing the body's natural ability to lower high blood glucose levels. It does this by increasing the levels of incretin hormones, which stimulate insulin release from the pancreas and suppress glucagon secretion, particularly in a glucose-dependent manner. Metformin, a biguanide, primarily reduces glucose production by the liver and improves insulin sensitivity in muscle cells.

This synergistic action helps to effectively manage blood sugar, especially when diet and exercise alone, or monotherapy with either component, are insufficient. The combination helps to achieve better glycemic control, reduce HbA1c levels, and mitigate the risk of diabetes-related complications.

Uses

• Treatment of type 2 diabetes mellitus.
• To improve blood glucose levels.
• Used as an adjunct to diet and exercise.
• When monotherapy is inadequate.

Directions For Use

Take orally with meals, usually once or twice daily, as directed by your physician.

Benefits

• Effective in lowering HbA1c levels.
• Reduces both fasting and post-meal glucose.
• Low risk of hypoglycemia.
• May contribute to modest weight loss (metformin).
• Improves pancreatic beta-cell function.
• Convenient fixed-dose combination.

Side Effects

• Nausea
• Diarrhea
• Abdominal discomfort
• Headache
• Upper respiratory tract infection
• Nasopharyngitis
• Joint pain
• Pancreatitis (rare)
• Kidney problems (rare)
• Lactic acidosis (rare, metformin)
• Vitamin B12 deficiency (metformin)
• Allergic reactions

Safety Measures

• Alcohol - Limit alcohol intake due to increased risk of lactic acidosis with metformin.
• Pregnancy - Not recommended during pregnancy; consult a doctor for suitable alternatives.
• Breastfeeding - Not advised during breastfeeding; seek medical advice.
• Liver - Contraindicated in severe liver impairment due to the metformin component.
• Kidney - Contraindicated in severe kidney impairment; dose adjustment needed for moderate impairment.
• Lung - Use with caution in severe respiratory conditions due to potential for lactic acidosis.

Disclaimer

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