SITAZIT 100 MG 10S

About

Sitagliptin is an oral antidiabetic drug belonging to the dipeptidyl peptidase-4 (DPP-4) inhibitor class, used for the management of type 2 diabetes mellitus. It works by enhancing the body's natural ability to lower high blood glucose levels. Sitagliptin increases the levels of incretin hormones, such as GLP-1 and GIP, which are released in response to meals. These hormones stimulate insulin synthesis and release from pancreatic beta cells in a glucose-dependent manner, meaning they primarily act when blood glucose is elevated, thereby reducing the risk of hypoglycemia.

Additionally, sitagliptin reduces glucagon secretion from pancreatic alpha cells, further contributing to improved glycemic control. This dual action helps to regulate blood sugar effectively. It is typically used as an adjunct to diet and exercise, either as monotherapy or in combination with other antidiabetic agents, to achieve better glycemic control in adult patients with type 2 diabetes.

Uses

• Management of type 2 diabetes mellitus.
• Adjunct to diet and exercise.
• Used alone or in combination with other antidiabetic agents.
• To improve glycemic control in adults.

Directions For Use

Take orally, usually once daily, with or without food, as directed by your physician.

Swallow the tablet whole with water; do not crush or chew.

Benefits

• Effectively lowers blood glucose levels.
• Low risk of hypoglycemia when used alone.
• Can be used as monotherapy or combination therapy.
• Generally well-tolerated.
• Convenient once-daily dosing.
• Improves pancreatic beta-cell function.

Side Effects

• Upper respiratory tract infection
• Nasopharyngitis
• Headache
• Diarrhea
• Nausea
• Abdominal pain
• Hypoglycemia (especially with sulfonylureas/insulin)
• Pancreatitis (rare)
• Allergic reactions (rash, urticaria)
• Joint pain (arthralgia)
• Kidney problems (rare, worsening renal function)
• Bullous pemphigoid (rare)

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake may affect blood sugar levels and should be discussed with a healthcare provider.
• Pregnancy - Use during pregnancy is generally not recommended unless clearly necessary, as there is limited data on human pregnancy. Consult your doctor.
• Breastfeeding - It is unknown if sitagliptin is excreted in human milk. A decision should be made whether to discontinue nursing or discontinue the drug, considering the importance of the drug to the mother.
• Liver - No dose adjustment is typically required for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment.
• Kidney - Dose adjustment is required for patients with moderate to severe renal impairment and end-stage renal disease. Regular monitoring of kidney function is advised.
• Lung - No specific precautions are generally needed for patients with lung conditions. However, any new or worsening respiratory symptoms should be reported to a doctor.

Disclaimer

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