About
Dapagliflozin 10mg and Metformin 500mg is a combination medication indicated for the treatment of type 2 diabetes mellitus. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine and a reduction in blood glucose levels. Metformin, a biguanide, reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity.
This synergistic combination targets multiple pathways involved in glucose regulation, providing comprehensive glycemic control. Beyond blood sugar reduction, dapagliflozin also offers cardiovascular and renal benefits, making this combination particularly advantageous for patients with co-existing heart or kidney conditions. It is used as an adjunct to diet and exercise.
Uses
- Management of type 2 diabetes mellitus.
- To improve glycemic control in adults.
- To reduce risk of cardiovascular death in certain patients.
- To reduce risk of hospitalization for heart failure.
Directions For Use
Take this medication orally, usually twice daily with meals, or as directed by your physician. Swallow the tablet whole.
Benefits
- Significantly lowers blood glucose and HbA1c.
- Reduces risk of cardiovascular events.
- Provides renal protective benefits.
- May lead to modest weight loss.
- Lowers blood pressure.
- Offers dual mechanism for comprehensive control.
Side Effects
- Genital yeast infections
- Urinary tract infections
- Increased urination
- Nausea
- Diarrhea
- Abdominal pain
- Metallic taste
- Dizziness
- Hypotension (low blood pressure)
- Ketoacidosis (rare but serious)
- Lactic acidosis (rare but serious)
- Dehydration
Safety Measures
- Alcohol - Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis (due to Metformin) and ketoacidosis (due to Dapagliflozin).
- Pregnancy - Not recommended during the second and third trimesters of pregnancy due to potential adverse effects on fetal kidney development.
- Breastfeeding - Not recommended during breastfeeding as both components may pass into breast milk. Consult a doctor.
- Liver - Use with caution in patients with liver impairment; Metformin is contraindicated in severe hepatic dysfunction due to increased lactic acidosis risk.
- Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to Metformin accumulation and reduced efficacy of Dapagliflozin.
- Lung - No specific contraindications related to lung conditions, but severe respiratory failure can increase lactic acidosis risk.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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