Adstem 24mg Injection

About

Adstem is a critical hematopoietic growth factor, typically a granulocyte colony-stimulating factor (G-CSF) analog, administered via subcutaneous injection. Its primary pharmacological action is to stimulate the production, maturation, and release of neutrophils from the bone marrow into the peripheral blood. Neutrophils are a vital component of the immune system, playing a crucial role in fighting bacterial and fungal infections. This medication is particularly important in preventing or treating severe neutropenia, a common and potentially life-threatening side effect of myelosuppressive chemotherapy, which significantly increases a patient's susceptibility to serious infections. By rapidly boosting the body's neutrophil count, Adstem helps to mitigate the risks associated with chemotherapy-induced neutropenia, allowing patients to maintain their treatment schedules, reduce the incidence of febrile neutropenia, and ultimately improve overall treatment outcomes and patient safety during cancer therapy.

Uses

• Prevention of febrile neutropenia after chemotherapy.
• Treatment of severe chronic neutropenia.
• Mobilization of peripheral blood progenitor cells.
• Management of neutropenia in specific conditions.

Directions For Use

Administer subcutaneously as directed by your healthcare provider. Follow aseptic technique and proper disposal of needles and syringes.

Benefits

• Reduces risk of infection.
• Shortens duration of neutropenia.
• Allows for on-schedule chemotherapy.
• Improves patient safety.
• Enhances immune recovery.
• Subcutaneous administration convenience.

Side Effects

• Bone pain
• Muscle pain
• Headache
• Fatigue
• Nausea
• Injection site reactions
• Splenomegaly (rare)
• Allergic reactions (rare)
• Thrombocytopenia (rare)
• Leukocytosis
• Elevated LDH
• Hypotension (rare)

Safety Measures

• Alcohol - No specific interaction with alcohol is known, but general moderation is advised during treatment.
• Pregnancy - Use only if clearly needed and potential benefits outweigh risks. Consult a physician.
• Breastfeeding - Exercise caution; it is unknown if it is excreted in human milk. Consult a physician.
• Liver - No specific dose adjustment required for liver impairment, but monitor overall patient condition.
• Kidney - No specific dose adjustment required for renal impairment, but monitor overall patient condition.
• Lung - Monitor for signs of acute respiratory distress syndrome (ARDS) or other serious pulmonary adverse events, though rare.

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