Nintenib 150mg Capsule

About

Nintenib Capsule is an oral multi-targeted tyrosine kinase inhibitor that plays a crucial role in the management of idiopathic pulmonary fibrosis (IPF) and certain types of advanced non-small cell lung cancer (NSCLC). In IPF, it works by inhibiting multiple growth factor receptors, including VEGFR, FGFR, and PDGFR, which are implicated in the pathogenesis of fibrosis. This action helps to slow the progression of lung function decline. In NSCLC, its anti-angiogenic and anti-proliferative effects target tumor growth and spread, particularly in combination with other chemotherapies. Its mechanism of action involves blocking intracellular signaling pathways essential for cell proliferation and survival, making it a valuable therapeutic agent in these challenging conditions.

The administration of Nintenib Capsule requires careful consideration of patient-specific factors, including disease stage, comorbidities, and potential drug interactions. Regular monitoring for adverse effects, particularly gastrointestinal disturbances and liver enzyme elevations, is essential throughout the treatment period. Dose adjustments may be necessary to manage side effects and optimize patient tolerance. Nintenib represents a significant advancement in the treatment landscape for both IPF, where it helps preserve lung function, and for specific advanced cancers, where it contributes to improved outcomes by targeting key molecular pathways involved in disease progression.

Uses

• Treatment of idiopathic pulmonary fibrosis (IPF).
• Management of progressive fibrosing interstitial lung diseases.
• Treatment of advanced non-small cell lung cancer (NSCLC).
• Therapy for systemic sclerosis-associated interstitial lung disease (SSc-ILD).

Directions For Use

Take orally twice daily with food, as prescribed by your physician. Swallow capsules whole; do not chew or open.

Benefits

• Slows progression of lung function decline in IPF.
• Effective in various fibrosing lung diseases.
• Targets multiple pathways in cancer.
• Oral administration for patient convenience.
• May improve survival in specific cancer types.
• Reduces risk of acute exacerbations in IPF.

Side Effects

• Diarrhea (very common)
• Nausea
• Vomiting
• Abdominal pain
• Elevated liver enzymes
• Fatigue
• Weight loss
• Hypertension
• Headache
• Rash
• Bleeding events (rare)
• Arterial thromboembolic events (rare)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption, especially due to the risk of liver enzyme elevation associated with this medication.
• Pregnancy - Highly contraindicated during pregnancy due to potential for severe fetal harm. Use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as it may be excreted in breast milk and harm the infant.
• Liver - Contraindicated in severe liver impairment. Use with caution and dose adjustment in mild to moderate impairment; monitor liver function closely.
• Kidney - Generally, no dose adjustment is needed for mild to moderate renal impairment. Use with caution in severe impairment.
• Lung - Specifically used for lung conditions (IPF, NSCLC). Monitor for worsening symptoms or new lung issues.

Disclaimer

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