Tepapro 15mg Injection

About

Pemetrexed is an antifolate antineoplastic agent that exerts its cytotoxic effects by disrupting folate-dependent metabolic pathways essential for DNA synthesis and cell replication. It inhibits several key enzymes, including thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), leading to the depletion of nucleotide precursors and subsequent inhibition of DNA and RNA synthesis. This mechanism makes it effective against rapidly dividing cancer cells. Pemetrexed is primarily indicated for the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma, often requiring folic acid and vitamin B12 supplementation to mitigate toxicity.

Uses

• Treatment of non-small cell lung cancer (NSCLC).
• Management of malignant pleural mesothelioma.
• Used as first-line therapy for advanced NSCLC.
• Maintenance therapy for advanced NSCLC.

Directions For Use

This medication is administered intravenously by a qualified healthcare professional.

Benefits

• Effective in specific types of lung cancer.
• Provides significant benefit in malignant pleural mesothelioma.
• Can be used as initial or maintenance therapy.
• Improves survival rates in eligible patients.
• Generally well-tolerated with appropriate pre-medication.
• Established safety and efficacy profile.

Side Effects

• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Fatigue or asthenia
• Nausea
• Vomiting
• Diarrhea
• Stomatitis (mouth sores)
• Skin rash
• Alopecia (hair loss)
• Fever
• Anorexia (loss of appetite)
• Peripheral edema

Safety Measures

• Alcohol - No specific interaction, but general caution is advised. Avoid excessive alcohol consumption.
• Pregnancy - Not recommended during pregnancy due to potential for fetal harm. Women of childbearing potential should use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and cause serious adverse effects in the infant.
• Liver - Use with caution in patients with liver impairment. Close monitoring of liver function tests is advised.
• Kidney - Contraindicated in severe renal impairment (creatinine clearance < 45 mL/min). Dose adjustment is required for moderate impairment.
• Lung - Monitor for rare but serious interstitial lung disease. Report any new or worsening respiratory symptoms promptly.

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