Flu Lifex 50mg Injection

About

Flu Lifex 50mg Injection contains Fludarabine, a potent purine analog antimetabolite primarily used in the management of B-cell chronic lymphocytic leukemia (CLL). Its mechanism involves intracellular phosphorylation to its active triphosphate form, which then inhibits DNA polymerase alpha, DNA primase, and ribonucleotide reductase. This inhibition disrupts DNA synthesis and repair, leading to programmed cell death in malignant lymphocytes. Fludarabine is particularly effective against quiescent and proliferating lymphocytes, making it a valuable agent in treating lymphoid malignancies.

The drug is administered intravenously and is often a key component in frontline and salvage regimens for CLL, especially in patients who have failed prior alkylating agent-based therapies. Due to its significant immunosuppressive properties, patients receiving Fludarabine require close monitoring for opportunistic infections and hematologic toxicities, including profound myelosuppression.

Uses

• Treatment of B-cell chronic lymphocytic leukemia (CLL).
• Management of refractory or relapsed CLL.
• Used in combination chemotherapy regimens for CLL.
• Induction of remission in CLL patients.

Directions For Use

Administered intravenously by a healthcare professional. Dosage and duration are determined by the treating physician.

Benefits

• High efficacy in CLL treatment.
• Induces significant remission rates.
• Improves overall survival in CLL.
• Effective in patients resistant to other therapies.
• Versatile for monotherapy or combination use.
• Well-tolerated in selected patient populations.

Side Effects

• Myelosuppression (anemia, neutropenia, thrombocytopenia)
• Fever and chills
• Infections (viral, bacterial, fungal)
• Nausea and vomiting
• Diarrhea
• Fatigue and weakness
• Skin rash
• Peripheral neuropathy
• Cough
• Pneumonia
• Tumor lysis syndrome

Safety Measures

• Alcohol - Avoid alcohol due to potential for increased gastrointestinal irritation and liver strain.
• Pregnancy - Contraindicated; highly teratogenic. Women of childbearing potential must use effective contraception.
• Breastfeeding - Contraindicated; may cause serious adverse effects in the infant.
• Liver - Use with caution in hepatic impairment; monitor liver function closely.
• Kidney - Dose adjustment required for renal impairment; contraindicated in severe renal impairment.
• Lung - Monitor for pulmonary toxicity (e.g., interstitial pneumonitis); discontinue if severe lung symptoms occur.

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