Fludara 50mg Injection

About

Fludarabine is a purine analog antimetabolite indicated for the treatment of B-cell chronic lymphocytic leukemia (CLL) in patients who have not responded to or whose disease has progressed during treatment with at least one prior standard alkylating agent-containing regimen. It acts by interfering with DNA synthesis and repair, leading to cell death, particularly in rapidly dividing cells like cancer cells. Fludarabine is phosphorylated intracellularly to its active metabolite, fludarabine triphosphate, which inhibits DNA polymerase alpha, DNA primase, and ribonucleotide reductase, thereby disrupting DNA replication and repair.

This cytotoxic action makes it a cornerstone in the treatment of CLL, often used in combination with other agents. Its efficacy in inducing remissions and improving survival in CLL patients has been well-documented. Due to its immunosuppressive effects, careful monitoring for infections and myelosuppression is essential during treatment.

Uses

• Treatment of B-cell chronic lymphocytic leukemia (CLL).
• Patients with CLL refractory to prior alkylating agents.
• Induction therapy for CLL.
• Part of combination regimens for CLL.

Directions For Use

Administered intravenously by a qualified healthcare professional. Strict adherence to dosage and administration guidelines is crucial.

Benefits

• Effective in refractory CLL.
• Induces high response rates.
• Improves progression-free survival in CLL.
• Well-established in CLL treatment protocols.
• Can be used as monotherapy or combination.
• Targets DNA synthesis in cancer cells.

Side Effects

• Myelosuppression (anemia, neutropenia, thrombocytopenia)
• Fever
• Infections
• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Rash
• Peripheral neuropathy
• Cough
• Pneumonia
• Tumor lysis syndrome

Safety Measures

• Alcohol - Avoid alcohol due to potential for increased gastrointestinal irritation and liver strain.
• Pregnancy - Contraindicated; highly teratogenic. Women of childbearing potential must use effective contraception.
• Breastfeeding - Contraindicated; may cause serious adverse effects in the infant.
• Liver - Use with caution in hepatic impairment; monitor liver function closely.
• Kidney - Dose adjustment required for renal impairment; contraindicated in severe renal impairment.
• Lung - Monitor for pulmonary toxicity (e.g., interstitial pneumonitis); discontinue if severe lung symptoms occur.

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