Zeparib 100mg Tablet

About

Olaparib is a pioneering poly (ADP-ribose) polymerase (PARP) inhibitor, representing a significant advancement in targeted cancer therapy. It is primarily utilized in the treatment of specific cancers, especially those harboring BRCA gene mutations or other homologous recombination repair deficiencies. PARP enzymes play a critical role in repairing single-strand DNA breaks. By inhibiting these enzymes, olaparib prevents cancer cells with already compromised DNA repair pathways, such as those with BRCA mutations, from effectively repairing their DNA damage. This accumulation of unrepaired DNA leads to genomic instability and ultimately triggers programmed cell death in these vulnerable cancer cells. This principle of synthetic lethality makes olaparib a crucial agent in precision oncology, offering a highly targeted and effective therapeutic strategy for patients with specific genetic profiles.

Uses

• BRCA-mutated ovarian cancer.
• BRCA-mutated HER2-negative metastatic breast cancer.
• Germline BRCA-mutated metastatic pancreatic adenocarcinoma.
• Homologous recombination repair gene-mutated metastatic castration-resistant prostate cancer.

Directions For Use

Take orally, usually twice daily, with or without food. Swallow tablets whole.

Benefits

• Targeted therapy for specific genetic mutations.
• Effective in BRCA-mutated cancers.
• Improves progression-free survival.
• Oral administration for patient convenience.
• Can be used as maintenance therapy.
• Reduces tumor burden.

Side Effects

• Nausea
• Vomiting
• Fatigue
• Anemia
• Diarrhea
• Decreased appetite
• Abdominal pain
• Headache
• Dysgeusia (taste disturbance)
• Myelosuppression (low blood counts)
• Pneumonitis (rare)
• Myelodysplastic syndrome/Acute myeloid leukemia (rare)

Safety Measures

• Alcohol - No specific contraindication, but avoid excessive intake as it may worsen gastrointestinal side effects.
• Pregnancy - Contraindicated; causes fetal harm. Use effective contraception during and for at least 6 months after treatment.
• Breastfeeding - Not recommended; unknown if excreted in human milk, but potential for serious adverse reactions in infants.
• Liver - Use with caution in moderate hepatic impairment; no dose adjustment needed for mild impairment.
• Kidney - Dose adjustment required in moderate renal impairment; use with caution in severe impairment.
• Lung - Rare cases of pneumonitis reported; monitor for new or worsening respiratory symptoms.

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